​COVID-19 gene vaccine project

COVID-19 gene vaccine project

1.  Determination of antigenic proteins

Based on the mechanism of COVID-19 infection in patients, the ideal antigen for COVID-19 was quickly determined:

·S (spike) protein

·N (nucleocapsid) protein

2.  Construction of gene vaccine

Construct a COVID-19 gene vaccine using a modified type 5 human adenovirus that does not have self replication ability as a vector, with the identified antigen protein gene as the target gene.

3.  Technical advantages

Based on the genetic technology advantages of Scinosen, efficiently clone the S and N protein genes in the RNA sequence of COVID-19, recombine them into adenovirus vectors, and construct active COVID-19 gene vaccine seeds.

Based on the powerful adenovirus vector CDMO platform, the key technology for loading antigen genes into viral vectors will promote the rapid technological transformation of COVID-19 gene vaccine.